More than 60 million Americans and more than 22 million Britons received their first dose of the two-dose Corona virus vaccine, and the United States allowed vaccines from Moderna and Pfizer, while the United Kingdom allowed the Pfizer vaccine, as well as the vaccine made by AstraZeneca and the University of Oxford, and some wonder how much protection a dose provides One of the Corona vaccine, and in the following lines we learn about the amount of protection provided by a single dose of the Pfizer, AstraZeneca and Moderna vaccines?
According to the American "Insider" site, the United Kingdom is postponing the second dose of vaccines for up to 12 weeks to give people the first vaccine.
In the United States, the Centers for Disease Control and Prevention recommended second doses of the Pfizer vaccine 21 days after the first, and 28 days after the first for Modena, with up to six weeks in "deterministic" situations.
The data on how effective vaccines are after a single dose are unclear, plus it depends on what you measure and when you measure them. Stephen Evans, professor of medical statistics at the London School of Hygiene and Tropical Medicine and a former member of the Medicines Safety Committee at the European Medicines Agency, said the Food Administration’s proposal And the US drug, the data from late-stage trials, was the best data available, and that's how much protection a single dose of each vaccine gives you, based on that data.
The efficacy of a single dose of Pfizer vaccine is 80%
The Pfizer dose was 52.4% effective in protecting against Corona symptoms, with symptoms appearing between the first and second dose, according to FDA documents, but the 52.4% figure includes 11 days before the start of protection after the first dose, so the real percentage may be higher.
The real value is between 29.5% and 84.5%, according to the Food and Drug Administration documents. There was a wide range because many people did not catch corona in the trial during this time period.
The Pfizer injection was 100% effective in protecting against hospitalization and death, this was dependent on a small number - only four people had symptoms of severe coronavirus in the trial after receiving a placebo instead of a vaccine.
Evans said there is "clear evidence" that you are getting at least 80% protection - and "probably" better than 90% - the Pfizer vaccine against symptoms of Corona after a single dose, and added that you cannot be completely sure what happens after 21 days because it has not been done. He fully tested it, and Evans noted that this was based on his overall reading of trial data that the FDA used in their briefing document prior to the FDA's mandate.
One dose of Moderna vaccine is 80% effective in preventing Corona symptoms.
Moderna vaccine was 69.5% effective in preventing Corona symptoms between the first and second dose, with a real value between 43.5% and 84.5%.
There was a fairly wide range because the number of people who contracted corona in the trial during this time period was low.
The 69.5% figure includes the 13 days before protection starts, so the true percentage may be higher.
There were a small number of people in the Moderna trial - about 7% - who had not received their second dose for unknown reasons.
In this group, the vaccine was 50.8% effective in preventing Corona symptoms for up to 14 days after the first dose and 92.1% effective after 14 days.
It is unclear to what extent a single dose of the vaccine will protect against hospitalization and death because many people have not contracted severe coronavirus - two in the vaccine group and four in the placebo.
Evans said you get at least 80% protection - and possibly better than 90% - for the Moderna vaccine against symptoms of Corona after a single 28-day dose After 28 days, it wasn't clear because it hadn't been tested.
The dose effectiveness of AstraZeneca vaccine is more than 70%.
Evans said it was difficult to ascertain the AstraZeneca vaccine number because late-stage trials used different study designs, and a large US study was ongoing.
The FDA has not yet provided dosage data in the same way it has provided with other vaccines.
A single dose of AstraZeneca was 76% effective in protecting against corona with symptoms appearing for at least 90 days, according to last-phase trial data published in The Lancet on February 19. The study authors also reported that a single dose offered 100% protection against hospitalization, but the numbers were few.
Based on his reading of current studies, Evans said that the efficacy of a single dose of AstraZeneca vaccine was likely at least 70% with symptoms appearing in the first 90 days and after this time period, it became unclear.
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