A study issued by Stony Brook University in America showed that the PLD1 gene is responsible for many congenital heart diseases of newborns, as the loss of this gene is the main responsible for the emergence of many heart diseases, according to what is reported by the Medical Express website.
And a team of researchers determined that the loss of PLD1 gene function may result in congenital defects in the right heart valve and neonatal cardiomyopathy, as congenital heart disease has been shown to be the most common type of birth defect, accounting for a third of all congenital anomalies, with an incidence of 7 in every thousand births. all over the world.
The majority of these defects include anomalies in the formation of the valves, and congenital right-sided heart disease includes abnormalities of the pulmonary valves and tricuspid valves.
The researchers relied on examining the PLD1 gene and its physiological role, in addition to the possibility of developing drugs that inhibit the activity of PLD1 for the treatment of stroke disorders and cancer, as it was found that the loss of PLD1 function in a recessive manner leads to congenital heart defects.
The study showed that the PLD gene is an enzyme present in all cells to generate a signal that changes how cells behave when they are stimulated by hormones, neurotransmitters and growth factors.
The decline in the performance of this gene may lead to many congenital heart diseases resulting from the growth of the heart valves on the right side of the heart and sometimes the ventricle, which may be a cause of high mortality in newborns.
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